منابع مشابه
The Notch Transcription Activation Complex Makes Its Move
Two papers in this issue of Cell, (Nam et al., 2006; Wilson and Kovall, 2006) report the crystal structure of the Notch transcriptional activation complex. These structures show that the ANK domain of Notch is an integral part of the transcription complex and supports MAM binding, whereas the RAM domain may trigger allosteric changes in the structure needed for the derepression of transcription.
متن کاملHow Mesp1 makes a move
The transcription factors Mesp1 and Mesp2 have essential roles in the migration and specification of multipotent progenitor cells at the onset of cardiogenesis. Chiapparo et al. (2016. J. Cell Biol http://dx.doi.org/10.1083/jcb.201505082) identify common Mesp functions in fate specification and Mesp1-specific targets controlling the speed and direction of progenitor cell migration.
متن کاملViroid trafficking: a small RNA makes a big move.
RNA trafficking has broad implications in the systemic spread of infectious agents, plant defense, and the systemic regulation of gene expression. The mechanisms that regulate trafficking remain poorly understood. The non-coding, infectious viroid RNAs are emerging as highly tractable model systems for the investigation of the basic mechanisms of RNA trafficking. Recent studies on viroids have ...
متن کاملWhat makes organic agriculture move - protest, meaning or market
Many different actors have hopes and aspirations for the future of organic agriculture. They have different perspectives on organic agriculture with different understandings of what it is and what makes it move. Each perspective entails a certain understanding of organic agriculture featuring certain concepts and values and a particular logic or rationality. It is important to acknowledge this ...
متن کاملFrom local to global: lipid emulsion (intralipid) makes a move.
I N clinical practice, lipid emulsion is used commonly as a component of parenteral nutrition. Lipid emulsion also is used as therapy for severe cardiotoxicity secondary to accidental overdose of local anesthetics, an effect that has been confirmed in animals and humans. Because patients with local anesthetic-induced cardiac arrest are considered to be less responsive for standard resuscitation...
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ژورنال
عنوان ژورنال: Nature
سال: 1990
ISSN: 0028-0836,1476-4687
DOI: 10.1038/348186a0